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Course Title: Clarinol™ CLA, the highest concentrated form of conjugated linoleic acid

Course Description: This course presents information regarding the benefits of Clarinol™ CLA in promoting effective weight management by reducing body fat and increasing lean muscle. Included in the discussion are the mechanisms of action, clinical evidence and the basis that Clarinol™ CLA is not only the highest concentrated form of CLA but the most effective form of CLA as well.

Overview: The presence of conjugated fatty acids in milk fat was first established over 66 years ago (Booth et al. 1935). Increased UV light absorption pointed to an increase in conjugated fatty acids in milk which was observed after cows were turned out to pasture in the spring.

In the early eighties, a substance isolated from grilled ground beef by Dr. Michael W. Pariza and his research team at the University of Wisconsin was found to inhibit the development of tumors in mice. After further study, the substance was identified as conjugated linoleic acid (CLA), a derivative of linoleic acid that is found widely in vegetable oils and animal fats.

Although CLA is a naturally occurring component of the human diet, it occurs at concentrations far too small to deliver the weight management benefits. In the US for example, with the trend towards a diet low in fats and increased use of a low fat or non-fat milk and other dairy products, the average CLA intake is estimated to be 160 to 430 mg/day. Beneficial effects, however, have been demonstrated at dosages of 2 grams to 3 grams per day¹. Achieving this level requires the supplementation through capsules, nutritional bars, shakes, and other potential functional food products containing Clarinol™ CLA.

The ability to maintain a healthy body weight and a low fat–to–muscle ratio is referred to as weight management. Dieting on the other hand refers to the active reduction of body fat over a specific period of time. It has been found that the period immediately following a diet can be a most frustrating time of trying to keep the lost weight off, in many cases all the weight and sometimes even more is gained back.

CLA has been found to promote the body’s natural fat metabolism making it easier to get your body in shape. Several studies investigating the effects of CLA on weight management and body composition confirm this. Studies show that supplementation with CLA (c9, t11 and the t10, c12 isomers in a 50:50 ratio) aids in weight management by promoting fat loss in healthy and overweight individuals. When weight is gained, or regained after a diet, CLA has been found to promote muscle growth as well as to inhibit the growth of fat cells improving the shape of the body.

Scientists now believe that CLA may have a unique effect on body fat by many means:

• By inhibiting the transport mechanism of fat into fat cells. This way the size of these cells is reduced, which may lead to an improved body shape.
• By enhancing the activity of an enzyme present in the muscles. By stimulating this enzyme, it helps the body to build up more lean muscle mass.

A number of studies have demonstrated that CLA reduces fat mass, while increasing lean body mass². A recent human study investigating the effect of 3.4g CLA/day in 180 normal healthy individuals led to a significant decrease (9%) in body fat compared with individuals not taking CLA⁴. In addition, another study in overweight populations demonstrated that at least 3.4 g CLA/d for a period of 12 weeks was necessary to see a significant reduction in body fat¹.

The chart below shows the Positive Effect on Lean Body Mass

A simple consumer friendly version of these scientific clinical studies for the physiological mechanism is as follows:

CLA works to reduce body fat by preventing fat accumulation in fat cells. Fat normally enters the fat cell through a “door” that is controlled by an enzyme, the “key”. By acting on this enzyme, or “key”, CLA keeps the “door” locked. When the “door” is locked, fat cannot enter the cells thereby not allowing the amount of fat to increase in the cells. The less fat that is present in the cells, the smaller and less mature they become, this helps to reduce the level of fat in the body. CLA works to increase lean muscle mass by enhancing the enzyme activity in muscle cells. The increased presence of fat will be burned in the muscle cells, thus building up lean muscle mass.

An overview of the studies showing an association between CLA and body composition:

In addition, a study published in the Journal of Food Chemistry and Toxicology demonstrates that an intake of 7.5 grams/day of Clarinol™ CLA for 1 year is safe in humans (Whigham, et al., 2004).

CLA is not a ‘magic bullet’ for weight management. However, using Clarinol™ CLA in conjunction with regular exercise and a healthy diet is essential for good body weight management. Some tips for combining Clarinol™ CLA and a healthy lifestyle include:

• Eating a variety of foods from the six food groups, and choose a diet low in fat.
• Consume sugar and alcohol in moderation.
• Alternate your workout routines throughout the course of the week to work different muscle groups.
• Lifting weights increases muscle mass, which helps to burn fat quicker – increasing your metabolic weight.

When consumed in recommended doses, results from Clarinol™ CLA can be seen in 8-12 weeks. This is the time taken to see a change in clinical studies which have been carried out to date.

Gram for gram, of all the CLA products on the market today, Clarinol™ CLA oil and powder offer the highest concentration (95%) of the beneficial active isomers (c9, t11 and t10, c12) responsible for weight management. This means less is required to achieve the same effects.

Clarinol™ CLA was the FIRST CLA to be ‘self-affirmed’ GRAS in the United States. Lipid Nutrition has completed the most extensive toxicology studies on Clarinol™ CLA according to OECD guidelines and thus can ensure the safety of Clarinol™ CLA

Clarinol™ CLA is also the CLA brand which had the highest percentage of women more satisfied with its results than the other CLA brands. 93% of women satisfied with Clarinol™ CLA compared to 78% of women using competition CLA (Citation: Consumer study of the marketplace conducted by Lightspeed Research and Lipid Nutrition of 800+ women who diet, exercise and/or take health supplements)

Yes, Clarinol™ CLA can be used with a low carb diet because Clarinol™ CLA itself is not a magic bullet and cannot help a consumer alone. Every clinical study has shown that in combination with dieting and exercise those taking Clarinol™ CLA see an increased difference in reduction of body fat and an increase of lean muscle leading to a more toned and shapely figure.

If Clarinol™ CLA prevents fat from being absorbed from the blood stream where does all the excess fat in the blood stream go?

Clarinol™ CLA only prevents fat from being absorbed by the body’s fat cells. It does not affect the uptake of fat to the Liver, Muscles or other tissues where it is required?

Continued evidence provides increased substantiation that CLA reduces body fat and increases lean muscle in humans when combined with a healthy diet and exercise. Clarinol™ CLA is the highest concentrated form of the active CLA isomers (c9, t11 & t10, c12) that are responsible for the weight management benefits. In addition, because Clarinol™ CLA is the highest concentrated form of the active CLA isomers (c9, t11 & t10, c12) it is also the CLA brand which had the highest percentage of women more satisfied with its results than the other CLA brands.

Clarinol™ CLA Multimedia based content

The video below is intended for students who have a broadband connection to the Internet.  The video is presented in the Windows Media Video format (.wmv).  You will need a media player that can view that type of file format.

Clarinol™ CLA - Internet Explorer users click here

Clarinol™ CLA - Netscape/Mozilla/FireFox users click here

To take the test for this course click here to add the course to the shopping cart.

Note: You will need to add the course to the shopping cart and create a nutrilearn.com account, if you don't already have one.  The test is FREE, but you need a nutrilearn.com account to access the test.  After you have completed the checkout process, you will be able to access the test through your nutrilearn.com profile. 

To access your profile, visit http://www.nutrilearn.com and click on "sign in".  Enter your email address and password you used when you created your nutrilearn account.  Once you are signed in to the system, click on "courses" in the top right corner of the page.  From there you will be able to see the link to the Clarinol™ CLA test.

References

1. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J. Nutr. 130:2943-2948 (2000).
2. Roche HM, Noone E, Nugent A, Gibney MJ. Conjugated linoleic acid: a novel therapeutic nutrient? Nutr. Res. Rev. 14:173–187 (2001).
3. Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans - Metabolic effects. Lipids 36:773–781 (2001).

4. Gaullier J-M. et al., "Conjugated linoleic acid (CLA) supplementation for one-year reduces body fat mass in healthy, overweight humans". American Journal of Clinical Nutrition, 2004; 79(6):1118-1125

5. Whigham LD, O'Shea M, Mohede IC, Walaski HP, Atkinson RL. Safety profile of conjugated linoleic acid in a 12-month trial in obese humans. Food Chem Toxicol. 2004 Oct;42(10):1701-9.

6. Mougios V, Matsakas A, Petridou A, Ring S, Sagredos A, Melissopoulou A, Tsigilis N, Nikolaidis M. Effect of supplementation with conjugated inoleic acid on human serum lipids and body fat. J Nutr Biochem 2001;12:585-94.

7. Kamphuis MMJW, Lejeune MPGM, Saris WHM, Westerterp-Plantinga MS. The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. Int J Obesity 2003; 27: 840-847.

8. Thom E, Wadstein J, Gudmundson O. Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res 2001;29:392-6.

The above statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat or prevent any disease.